لتروزول مرک MERCK 182541
تولید کمپانی مرک MERCK
ساخت کشور آلمان
حجم 25 گرم
کد مرک 182541
دارای گواهی و ستریفیکیت
MSDS COA
کاتالوگ فنی کمپانی مرک MERCK 182541
Overview
An orally bioavailable non-steroidal triazole compound that acts as a potent and selective inhibitor of aromatase (IC50 = 140, 350 and 450 pM in Dex-treated fibroblasts, MCF-7Ca, and JEG-3 cells, respectively). Competitively, but reversibly binds to the heme iron of aromatase. Does not affect the synthesis of adrenal mineralocorticoid or glucocorticoids. Reported to be highly effective as an anti-estrogenic and anti-proliferative agent in estrogen-rich tumors. Also delays the fusing of the growth plates in adolescents and enhances the effectiveness of growth hormone. Shown to synergistically induce apoptosis and cause tumor regression when combined with IGF-1R inhibitors.
Catalogue Number 182541
Brand Family Calbiochem®
Synonyms 4,4ʹ-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, 1-(bis-(4-Cyanophenyl)methyl)-1,2,4-triazole
CAS number 112809-51-5
Form White powder
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaged under inert gas Packaged under inert gas
